Higher levels of CSF homovanillic acid in recently abstinent cocaine-dependent patients.
Journal Article (Journal Article)
OBJECTIVE: The authors examined an index of dopaminergic neurotransmission in recently abstinent cocaine-dependent patients. METHOD: CSF concentrations of the dopamine metabolite homovanillic acid (HVA) were determined in 30 recently abstinent cocaine-dependent patients and 69 healthy comparison subjects. RESULTS: The cocaine-dependent patients had a significantly higher mean concentration of CSF HVA than did the healthy comparison group. CONCLUSIONS: Recently abstinent cocaine-dependent patients may show dysregulation of the central dopaminergic system.
Full Text
Duke Authors
Cited Authors
- Roy, A; Berman, J; Williams, R; Kuhn, C; Gonzalez, B
Published Date
- June 2002
Published In
Volume / Issue
- 159 / 6
Start / End Page
- 1053 - 1055
PubMed ID
- 12042199
International Standard Serial Number (ISSN)
- 0002-953X
Digital Object Identifier (DOI)
- 10.1176/appi.ajp.159.6.1053
Language
- eng
Conference Location
- United States