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Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy.

Publication ,  Journal Article
Walker, QD; Cabassa, J; Kaplan, KA; Li, ST; Haroon, J; Spohr, HA; Kuhn, CM
Published in: Neuropsychopharmacology
July 2001

Sex differences in biological substrates of drug use and addiction are poorly understood. The present study investigated sexual dimorphisms in motor behavior following acute cocaine administration (10, 20, or 40 mg/kg, i.p.). Cocaine increased stereotypy rating, horizontal and vertical activity in both sexes, and effects were always greater in females than males. A population analysis using data from multiple experiments indicated that horizontal activity scores were normally distributed in males but not in females. Gonadectomy induced disparate effects on cocaine-stimulated motor behavior. Population analysis indicated that castrated males exhibited more horizontal activity and stereotypy than shams. Ovariectomy did not affect cocaine-stimulated stereotypy but did attenuate horizontal activity in a subset of rats that had not been vaginally lavaged. In summary, gonadectomy effects were sex and behavioral topography specific and indicate that activational effects of gonadal hormones partially mediate the robust sex differences in cocaine-stimulated open-field behavior.

Duke Scholars

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

July 2001

Volume

25

Issue

1

Start / End Page

118 / 130

Location

England

Related Subject Headings

  • Steroids
  • Stereotyped Behavior
  • Sex Characteristics
  • Rats, Sprague-Dawley
  • Rats
  • Psychiatry
  • Ovariectomy
  • Orchiectomy
  • Motor Activity
  • Male
 

Citation

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ICMJE
MLA
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Walker, Q. D., Cabassa, J., Kaplan, K. A., Li, S. T., Haroon, J., Spohr, H. A., & Kuhn, C. M. (2001). Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy. Neuropsychopharmacology, 25(1), 118–130. https://doi.org/10.1016/S0893-133X(00)00248-7
Walker, Q. D., J. Cabassa, K. A. Kaplan, S. T. Li, J. Haroon, H. A. Spohr, and C. M. Kuhn. “Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy.Neuropsychopharmacology 25, no. 1 (July 2001): 118–30. https://doi.org/10.1016/S0893-133X(00)00248-7.
Walker QD, Cabassa J, Kaplan KA, Li ST, Haroon J, Spohr HA, et al. Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy. Neuropsychopharmacology. 2001 Jul;25(1):118–30.
Walker, Q. D., et al. “Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy.Neuropsychopharmacology, vol. 25, no. 1, July 2001, pp. 118–30. Pubmed, doi:10.1016/S0893-133X(00)00248-7.
Walker QD, Cabassa J, Kaplan KA, Li ST, Haroon J, Spohr HA, Kuhn CM. Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy. Neuropsychopharmacology. 2001 Jul;25(1):118–130.
Journal cover image

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

July 2001

Volume

25

Issue

1

Start / End Page

118 / 130

Location

England

Related Subject Headings

  • Steroids
  • Stereotyped Behavior
  • Sex Characteristics
  • Rats, Sprague-Dawley
  • Rats
  • Psychiatry
  • Ovariectomy
  • Orchiectomy
  • Motor Activity
  • Male