Sex, steroids, and stimulant sensitivity.

Journal Article (Journal Article)

The current study investigated ovarian modulation of the locomotor response to cocaine in rats. Ovariectomy in females lowered the response to cocaine (10 mg/kg i.p.), whereas castration did not change that of males. The locomotor responses of prepubertal males and females to cocaine were similar. However, the postpubertal sex difference resulted from a fall in cocaine-stimulated locomotion in males rather than a rise in females. Neonatal testosterone treatment of female rat pups decreased the response to cocaine in adulthood. These findings suggest that both the activational and organizational effects of gonadal steroids contribute to the greater response of females to cocaine.

Full Text

Duke Authors

Cited Authors

  • Kuhn, CM; Walker, QD; Kaplan, KA; Li, ST

Published Date

  • June 2001

Published In

Volume / Issue

  • 937 /

Start / End Page

  • 188 - 201

PubMed ID

  • 11458537

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2001.tb03565.x


  • eng

Conference Location

  • United States