Intermittent and continuous cocaine administration: residual behavioral states during withdrawal.

Published

Journal Article

Rats were pretreated with 40 mg/kg/day cocaine for 14 days by either subcutaneous injections or osmotic minipumps. Rats were then withdrawn from the pretreatment regime for 1 or 7 days and given a 20-mg/kg IP cocaine challenge (day 1) or a 0-, 10-, 20-, or 40-mg/kg IP cocaine challenge (day 7). The results indicate that rats receiving intermittent, daily injections exhibited sensitization to the behavioral effects of a cocaine challenge on days 1 and 7 of withdrawal. In contrast, rats receiving continuous cocaine exhibited tolerance to the behavioral effects of a cocaine challenge on days 1 and 7 of withdrawal. The present results support and extend previous research that indicates that the route and temporal pattern of administration influences the effects of chronic cocaine. Furthermore, the present results indicate that the continuous infusion paradigm may represent an alternative animal model of some aspects of high-dose cocaine abuse, as compared to the typical procedure of single, or multiple, daily cocaine injections.

Full Text

Duke Authors

Cited Authors

  • King, GR; Joyner, C; Lee, T; Kuhn, C; Ellinwood, EH

Published Date

  • September 1992

Published In

Volume / Issue

  • 43 / 1

Start / End Page

  • 243 - 248

PubMed ID

  • 1409810

Pubmed Central ID

  • 1409810

International Standard Serial Number (ISSN)

  • 0091-3057

Language

  • eng

Conference Location

  • United States