Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.

Journal Article (Journal Article)

The occurrence of adverse extrapyramidal effects following metoclopramide (MCP) therapy has been well documented in humans. In rats, MCP produced catalepsy and inhibited apomorphine-induced stereotypy, locomotor activity, and rotational behavior. MCP also accelerated dopamine turnover, potently stimulated prolactin release, and, at high concentrations, inhibited [3H]spiperone binding to striatal membranes. These behavioral and biochemical effects induced by MCP were similar to those observed with haloperidol. We conclude that MCP possesses most of the pharmacological properties of neuroleptic agents.

Full Text

Duke Authors

Cited Authors

  • Hassan, MN; Reches, A; Kuhn, C; Higgins, D; Fahn, S

Published Date

  • 1986

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 71 - 78

PubMed ID

  • 3829008

International Standard Serial Number (ISSN)

  • 0362-5664

Digital Object Identifier (DOI)

  • 10.1097/00002826-198602000-00008


  • eng

Conference Location

  • United States