Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.
Journal Article (Journal Article)
The occurrence of adverse extrapyramidal effects following metoclopramide (MCP) therapy has been well documented in humans. In rats, MCP produced catalepsy and inhibited apomorphine-induced stereotypy, locomotor activity, and rotational behavior. MCP also accelerated dopamine turnover, potently stimulated prolactin release, and, at high concentrations, inhibited [3H]spiperone binding to striatal membranes. These behavioral and biochemical effects induced by MCP were similar to those observed with haloperidol. We conclude that MCP possesses most of the pharmacological properties of neuroleptic agents.
Full Text
Duke Authors
Cited Authors
- Hassan, MN; Reches, A; Kuhn, C; Higgins, D; Fahn, S
Published Date
- 1986
Published In
Volume / Issue
- 9 / 1
Start / End Page
- 71 - 78
PubMed ID
- 3829008
International Standard Serial Number (ISSN)
- 0362-5664
Digital Object Identifier (DOI)
- 10.1097/00002826-198602000-00008
Language
- eng
Conference Location
- United States