LKLF: A transcriptional regulator of single-positive T cell quiescence and survival.

Published

Journal Article

Mature single-positive (SP) T lymphocytes enter a "resting" state in which they are proliferatively quiescent and relatively resistant to apoptosis. The molecular mechanisms regulating this quiescent phenotype were unknown. Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell activation. LKLF-deficient T cells produced by gene targeting had a spontaneously activated phenotype and died in the spleen and lymph nodes from Fas ligand-induced apoptosis. Thus, LKLF is required to program the quiescent state of SP T cells and to maintain their viability in the peripheral lymphoid organs and blood.

Full Text

Duke Authors

Cited Authors

  • Kuo, CT; Veselits, ML; Leiden, JM

Published Date

  • September 26, 1997

Published In

Volume / Issue

  • 277 / 5334

Start / End Page

  • 1986 - 1990

PubMed ID

  • 9302292

Pubmed Central ID

  • 9302292

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.277.5334.1986

Language

  • eng

Conference Location

  • United States