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Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.

Publication ,  Journal Article
Slager, SL; Camp, NJ; Conde, L; Shanafelt, TD; Achenbach, SJ; Rabe, KG; Kay, NE; Novak, AJ; Call, TG; Bracci, PM; Sille, FMC; Sanchez, S ...
Published in: Br J Haematol
December 2012

A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10(-3)). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.

Duke Scholars

Published In

Br J Haematol

DOI

EISSN

1365-2141

Publication Date

December 2012

Volume

159

Issue

5

Start / End Page

572 / 576

Location

England

Related Subject Headings

  • bcl-2 Homologous Antagonist-Killer Protein
  • Polymorphism, Single Nucleotide
  • Lymphoma, Non-Hodgkin
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Immunology
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Markers
  • DNA, Neoplasm
 

Citation

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Slager, S. L., Camp, N. J., Conde, L., Shanafelt, T. D., Achenbach, S. J., Rabe, K. G., … Cerhan, J. R. (2012). Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. Br J Haematol, 159(5), 572–576. https://doi.org/10.1111/bjh.12070
Slager, Susan L., Nicola J. Camp, Lucia Conde, Tait D. Shanafelt, Sara J. Achenbach, Kari G. Rabe, Neil E. Kay, et al. “Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.Br J Haematol 159, no. 5 (December 2012): 572–76. https://doi.org/10.1111/bjh.12070.
Slager SL, Camp NJ, Conde L, Shanafelt TD, Achenbach SJ, Rabe KG, et al. Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. Br J Haematol. 2012 Dec;159(5):572–6.
Slager, Susan L., et al. “Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.Br J Haematol, vol. 159, no. 5, Dec. 2012, pp. 572–76. Pubmed, doi:10.1111/bjh.12070.
Slager SL, Camp NJ, Conde L, Shanafelt TD, Achenbach SJ, Rabe KG, Kay NE, Novak AJ, Call TG, Bracci PM, Sille FMC, Sanchez S, Akers NK, Cunningham JM, Serie DJ, McDonnell SK, Leis JF, Wang AH, Weinberg JB, Glenn M, Link B, Vachon CM, Lanasa MC, Skibola CF, Cerhan JR. Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. Br J Haematol. 2012 Dec;159(5):572–576.
Journal cover image

Published In

Br J Haematol

DOI

EISSN

1365-2141

Publication Date

December 2012

Volume

159

Issue

5

Start / End Page

572 / 576

Location

England

Related Subject Headings

  • bcl-2 Homologous Antagonist-Killer Protein
  • Polymorphism, Single Nucleotide
  • Lymphoma, Non-Hodgkin
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Immunology
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Markers
  • DNA, Neoplasm