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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.

Publication ,  Journal Article
Conde, L; Halperin, E; Akers, NK; Brown, KM; Smedby, KE; Rothman, N; Nieters, A; Slager, SL; Brooks-Wilson, A; Agana, L; Riby, J; Liu, J ...
Published in: Nat Genet
August 2010

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).

Duke Scholars

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

August 2010

Volume

42

Issue

8

Start / End Page

661 / 664

Location

United States

Related Subject Headings

  • Risk Factors
  • Major Histocompatibility Complex
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Follicular
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Disease Susceptibility
  • Developmental Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Conde, L., Halperin, E., Akers, N. K., Brown, K. M., Smedby, K. E., Rothman, N., … Skibola, C. F. (2010). Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet, 42(8), 661–664. https://doi.org/10.1038/ng.626
Conde, Lucia, Eran Halperin, Nicholas K. Akers, Kevin M. Brown, Karin E. Smedby, Nathaniel Rothman, Alexandra Nieters, et al. “Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.Nat Genet 42, no. 8 (August 2010): 661–64. https://doi.org/10.1038/ng.626.
Conde L, Halperin E, Akers NK, Brown KM, Smedby KE, Rothman N, et al. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet. 2010 Aug;42(8):661–4.
Conde, Lucia, et al. “Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.Nat Genet, vol. 42, no. 8, Aug. 2010, pp. 661–64. Pubmed, doi:10.1038/ng.626.
Conde L, Halperin E, Akers NK, Brown KM, Smedby KE, Rothman N, Nieters A, Slager SL, Brooks-Wilson A, Agana L, Riby J, Liu J, Adami H-O, Darabi H, Hjalgrim H, Low H-Q, Humphreys K, Melbye M, Chang ET, Glimelius B, Cozen W, Davis S, Hartge P, Morton LM, Schenk M, Wang SS, Armstrong B, Kricker A, Milliken S, Purdue MP, Vajdic CM, Boyle P, Lan Q, Zahm SH, Zhang Y, Zheng T, Becker N, Benavente Y, Boffetta P, Brennan P, Butterbach K, Cocco P, Foretova L, Maynadié M, de Sanjosé S, Staines A, Spinelli JJ, Achenbach SJ, Call TG, Camp NJ, Glenn M, Caporaso NE, Cerhan JR, Cunningham JM, Goldin LR, Hanson CA, Kay NE, Lanasa MC, Leis JF, Marti GE, Rabe KG, Rassenti LZ, Spector LG, Strom SS, Vachon CM, Weinberg JB, Holly EA, Chanock S, Smith MT, Bracci PM, Skibola CF. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet. 2010 Aug;42(8):661–664.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

August 2010

Volume

42

Issue

8

Start / End Page

661 / 664

Location

United States

Related Subject Headings

  • Risk Factors
  • Major Histocompatibility Complex
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Follicular
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Disease Susceptibility
  • Developmental Biology