Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
Conde, L; Halperin, E; Akers, NK; Brown, KM; Smedby, KE; Rothman, N; Nieters, A; Slager, SL; Brooks-Wilson, A; Agana, L; Riby, J; Liu, J; Adami, H-O; Darabi, H; Hjalgrim, H; Low, H-Q; Humphreys, K; Melbye, M; Chang, ET; Glimelius, B; Cozen, W; Davis, S; Hartge, P; Morton, LM; Schenk, M; Wang, SS; Armstrong, B; Kricker, A; Milliken, S; Purdue, MP; Vajdic, CM; Boyle, P; Lan, Q; Zahm, SH; Zhang, Y; Zheng, T; Becker, N; Benavente, Y; Boffetta, P; Brennan, P; Butterbach, K; Cocco, P; Foretova, L; Maynadié, M; de Sanjosé, S; Staines, A; Spinelli, JJ; Achenbach, SJ; Call, TG; Camp, NJ; Glenn, M; Caporaso, NE; Cerhan, JR; Cunningham, JM; Goldin, LR; Hanson, CA; Kay, NE; Lanasa, MC; Leis, JF; Marti, GE; Rabe, KG; Rassenti, LZ; Spector, LG; Strom, SS; Vachon, CM; Weinberg, JB; Holly, EA; Chanock, S; Smith, MT; Bracci, PM; Skibola, CF
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