Pharmacokinetics of a transdermal nicotine patch compared to nicotine gum


Journal Article

A new transdermal nicotine delivery system (TBS-NCT)was investigated in laboratory and clinical studies with healthy cigarette smokers. Plasma nicotine concentration time profiles were characterized during and after 24-hr application of three doses of TBS-NCT and during and after a 6-hr regimen of nicotine polacrilex gum. Pharmacokinetic analysis revealed dose-related plasma concentrations for transdermal treatments, bracketing the concentrations obtained from nicotine gum. The TBS-NCT system was also well tolerated during a subsequent 4-week open trial and demonstrated a 40% success rate for smoking cessation during the course of the trial. Overall, the TBS-NCT system appears suitable for once-daily application as an aid in smoking cessation treatments. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Full Text

Duke Authors

Cited Authors

  • Lane, JD; Westman, EC; Ripka, GV; Wu, J; Chiang, CC; Rose, JE

Published Date

  • January 1, 1993

Published In

Volume / Issue

  • 19 / 16

Start / End Page

  • 1999 - 2010

International Standard Serial Number (ISSN)

  • 0363-9045

Digital Object Identifier (DOI)

  • 10.3109/03639049309069337

Citation Source

  • Scopus