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Comparison of human and Xenopus GATA-2 promoters.

Publication ,  Journal Article
Fleenor, DE; Langdon, SD; deCastro, CM; Kaufman, RE
Published in: Gene
November 14, 1996

GATA proteins comprise a family of transcription factors that are required for appropriate development of hematopoietic lineages. In order to understand the transcriptional regulation of GATA genes, we have cloned the human GATA-2 gene and identified and characterized its promoter. Comparison with the Xenopus GATA-2 promoter demonstrates highly conserved CCAAT box elements, which are essential for appropriate Xenopus expression. Unlike the Xenopus gene, the human GATA-2 gene lacks GATA binding motifs within the first 800 bp of 5' flanking sequence. In addition, the human GATA-2 promoter has two highly conserved ets sites that resemble the binding site for a recently described ets repressor factor, ERF. These conserved DNA sequence motifs provide strong candidate regions for the regulation of GATA-2.

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Published In

Gene

DOI

ISSN

0378-1119

Publication Date

November 14, 1996

Volume

179

Issue

2

Start / End Page

219 / 223

Location

Netherlands

Related Subject Headings

  • Xenopus Proteins
  • Xenopus
  • Transcription Factors
  • Sequence Homology, Nucleic Acid
  • Promoter Regions, Genetic
  • Molecular Sequence Data
  • Humans
  • GATA2 Transcription Factor
  • Developmental Biology
  • DNA-Binding Proteins
 

Citation

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Fleenor, D. E., Langdon, S. D., deCastro, C. M., & Kaufman, R. E. (1996). Comparison of human and Xenopus GATA-2 promoters. Gene, 179(2), 219–223. https://doi.org/10.1016/s0378-1119(96)00355-1
Fleenor, D. E., S. D. Langdon, C. M. deCastro, and R. E. Kaufman. “Comparison of human and Xenopus GATA-2 promoters.Gene 179, no. 2 (November 14, 1996): 219–23. https://doi.org/10.1016/s0378-1119(96)00355-1.
Fleenor DE, Langdon SD, deCastro CM, Kaufman RE. Comparison of human and Xenopus GATA-2 promoters. Gene. 1996 Nov 14;179(2):219–23.
Fleenor, D. E., et al. “Comparison of human and Xenopus GATA-2 promoters.Gene, vol. 179, no. 2, Nov. 1996, pp. 219–23. Pubmed, doi:10.1016/s0378-1119(96)00355-1.
Fleenor DE, Langdon SD, deCastro CM, Kaufman RE. Comparison of human and Xenopus GATA-2 promoters. Gene. 1996 Nov 14;179(2):219–223.
Journal cover image

Published In

Gene

DOI

ISSN

0378-1119

Publication Date

November 14, 1996

Volume

179

Issue

2

Start / End Page

219 / 223

Location

Netherlands

Related Subject Headings

  • Xenopus Proteins
  • Xenopus
  • Transcription Factors
  • Sequence Homology, Nucleic Acid
  • Promoter Regions, Genetic
  • Molecular Sequence Data
  • Humans
  • GATA2 Transcription Factor
  • Developmental Biology
  • DNA-Binding Proteins