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Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis.

Publication ,  Journal Article
Lightfoot, HM; Lark, A; Livasy, CA; Moore, DT; Cowan, D; Dressler, L; Craven, RJ; Cance, WG
Published in: Breast Cancer Res Treat
November 2004

Focal adhesion kinase (FAK) is a protein tyrosine kinase that is overexpressed in a subset of invasive breast cancers. FAK transmits signals that mediate several functions including tumor cell proliferation, migration, adhesion and survival. We used immunohistochemical techniques to assess FAK expression in patients with fibrocystic disease (FCD), atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC). Formalin-fixed, paraffin-embedded (FFPE) tissue sections were obtained from 119 patients (12 FCD, 38 ADH, 51 DCIS and 18 IDC). The anti-FAK 4.47 monoclonal antibody was used to detect FAK expression. FAK expression was scored as high (3 or 4 intensity and > or =90% positive cells) or low. The DCIS tissue sections demonstrated high FAK expression in 34/51 (66%) of the sections. High FAK expression was demonstrated in 6/18 (33%) of the IDC tissue sections and 8/38 (21%) of the ADH tissue sections. None (0/12) of the FCD tissues sections stained high for FAK. The pattern of FAK expression in DCIS was significantly higher than ADH (p < 0.0001) and IDC (p = 0.02). We conclude that FAK overexpression in preinvasive, DCIS tumors precedes tumor cell invasion or metastasis, suggesting that FAK may function as a survival signal and be an early event in breast tumorigenesis.

Duke Scholars

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

November 2004

Volume

88

Issue

2

Start / End Page

109 / 116

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Immunohistochemistry
  • Hyperplasia
  • Humans
  • Gene Expression Profiling
  • Focal Adhesion Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 1
  • Fibrocystic Breast Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lightfoot, H. M., Lark, A., Livasy, C. A., Moore, D. T., Cowan, D., Dressler, L., … Cance, W. G. (2004). Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat, 88(2), 109–116. https://doi.org/10.1007/s10549-004-1022-8
Lightfoot, Harry M., Amy Lark, Chad A. Livasy, Dominic T. Moore, David Cowan, Lynn Dressler, Rolf J. Craven, and William G. Cance. “Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis.Breast Cancer Res Treat 88, no. 2 (November 2004): 109–16. https://doi.org/10.1007/s10549-004-1022-8.
Lightfoot HM, Lark A, Livasy CA, Moore DT, Cowan D, Dressler L, et al. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat. 2004 Nov;88(2):109–16.
Lightfoot, Harry M., et al. “Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis.Breast Cancer Res Treat, vol. 88, no. 2, Nov. 2004, pp. 109–16. Pubmed, doi:10.1007/s10549-004-1022-8.
Lightfoot HM, Lark A, Livasy CA, Moore DT, Cowan D, Dressler L, Craven RJ, Cance WG. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat. 2004 Nov;88(2):109–116.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

November 2004

Volume

88

Issue

2

Start / End Page

109 / 116

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Immunohistochemistry
  • Hyperplasia
  • Humans
  • Gene Expression Profiling
  • Focal Adhesion Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 1
  • Fibrocystic Breast Disease