Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.

Journal Article (Journal Article)

Cultured rat retinal astrocytes were tested by indirect immunofluorescence staining for their ability to express class I and II major histocompatibility complex (MHC) antigens under basal culture conditions and after three days of stimulation with two recombinant cytokines, rat interferon-gamma (IFN-gamma) and human tumour necrosis factor alpha (TNF alpha). Under basal culture conditions low levels of class I antigens were detected on a small percentage of cells, but there was no visible class II. IFN-gamma and TNF alpha stimulation enhanced class I expression. TNF alpha had no effect on class II expression, whereas IFN-gamma induced the expression of class II in a dose dependent manner. These findings suggest that retinal astrocytes might play a part in immunological events occurring in the retina.

Full Text

Duke Authors

Cited Authors

  • el-Asrar, AM; Maimone, D; Morse, PH; Lascola, C; Reder, AT

Published Date

  • August 1991

Published In

Volume / Issue

  • 75 / 8

Start / End Page

  • 473 - 475

PubMed ID

  • 1908315

Pubmed Central ID

  • PMC1042434

International Standard Serial Number (ISSN)

  • 0007-1161

Digital Object Identifier (DOI)

  • 10.1136/bjo.75.8.473


  • eng

Conference Location

  • England