The scientific basis for evaluation and management of thrombotic disorders.
Journal Article (Review)
The hemostatic mechanisms at work in the body involve a complex series of interactions between platelets, the endothelium, and the coagulation cascade. Much has been learned regarding the molecular mechanisms governing these intricate processes. The hypercoagulable state involves a disruption of the normal homeostatic equilibrium. This state may be either inherent or acquired. The prevention of associated thromboembolic complications requires therapeutic anticoagulation. A broader understanding of the factors contributing to these prothrombotic tendencies and the subtleties involved in their management provides the surgeon with another weapon in the armamentarium to promote better and safer patient outcomes.
Full Text
Duke Authors
Cited Authors
- Olcese, VA; Stirling, M; Lawson, J
Published Date
- November 2006
Published In
Volume / Issue
- 16 / 4
Start / End Page
- 435 - 443
PubMed ID
- 17240828
Pubmed Central ID
- 17240828
International Standard Serial Number (ISSN)
- 1547-4127
Digital Object Identifier (DOI)
- 10.1016/j.thorsurg.2006.07.003
Language
- eng
Conference Location
- United States