Altered renal proximal tubule cell ion homeostasis during diabetes


Journal Article

The use of electron probe x-ray microanalysis (EPXMA) to acquire quantitative micromechanical images of proximal tubule cells from diabetic rats is studied to define how subcellular ion homeostasis is altered during diabetes. During the experiment, proximal tubule cells from streptozotocin-diabetic rats as models experienced several changes in intracellular ionic distributions. These results suggest that basic mechanisms for ion transport in renal tubule cells are changed during diabetes and that glucose-stimulated increases in Na levels alter the distribution of other ions via putative Na-dependent co-transport and counter-transport mechanisms across proximal tubule plasma and organelle membranes.

Duke Authors

Cited Authors

  • Freudenrich, CC; Hockett, D; Kirk, B; Gilliland, K; Scherer, B; Winter, K; Ingram, P; LeFurgey, A

Published Date

  • December 1, 1993

Published In

  • Proceedings Annual Meeting, Microscopy Society of America

Start / End Page

  • 12 - 13

International Standard Serial Number (ISSN)

  • 0424-8201

Citation Source

  • Scopus