Limiting lumens: A new role for Cdc42

Journal Article

The formation of a single lumen is a necessary step in the formation of biological tubes. Different tissues have developed diverse ways to form their lumens. In this issue, Jaffe et al. (Jaffe, A.B., N. Kaji, J. Durgan, and A. Hall. 2008. J. Cell Biol. 183:625 - 633) report the development of an in vitro system for studying lumen formation that is driven by fl uid transport, recapitulating intestinal lumen formation. Effective ion and fl uid transport requires both cell polarity and proper tissue organization. Surprisingly, polarization of cells in this three-dimensional system does not require Cdc42. Instead, Cdc42 prevents formation of multiple lumens by orienting cell divisions and directing apical membrane biogenesis. © 2008 Lechler.

Full Text

Duke Authors

Cited Authors

  • Lechler, T

Published Date

  • 2008

Published In

Volume / Issue

  • 183 / 4

Start / End Page

  • 575 - 577

PubMed ID

  • 19001130

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.200809174