Limiting lumens: A new role for Cdc42
Journal Article
The formation of a single lumen is a necessary step in the formation of biological tubes. Different tissues have developed diverse ways to form their lumens. In this issue, Jaffe et al. (Jaffe, A.B., N. Kaji, J. Durgan, and A. Hall. 2008. J. Cell Biol. 183:625 - 633) report the development of an in vitro system for studying lumen formation that is driven by fl uid transport, recapitulating intestinal lumen formation. Effective ion and fl uid transport requires both cell polarity and proper tissue organization. Surprisingly, polarization of cells in this three-dimensional system does not require Cdc42. Instead, Cdc42 prevents formation of multiple lumens by orienting cell divisions and directing apical membrane biogenesis. © 2008 Lechler.
Full Text
Duke Authors
Cited Authors
- Lechler, T
Published Date
- 2008
Published In
Volume / Issue
- 183 / 4
Start / End Page
- 575 - 577
PubMed ID
- 19001130
International Standard Serial Number (ISSN)
- 0021-9525
Digital Object Identifier (DOI)
- 10.1083/jcb.200809174