Coordinating cytoskeletal tracks to polarize cellular movements

Journal Article

For many years after the discovery of actin filaments and microtubules, it was widely assumed that their polymerization, organization, and functions were largely distinct. However, in recent years it has become increasingly apparent that coordinated interactions between microtubules and filamentous actin are involved in many polarized processes, including cell shape, mitotic spindle orientation, motility, growth cone guidance, and wound healing. In the past few years, significant strides have been made in unraveling the intricacies that govern these intertwined cytoskeletal rearrangements.

Full Text

Duke Authors

Cited Authors

  • Kodama, A; Lechler, T; Fuchs, E

Published Date

  • 2004

Published In

  • Journal of Cell Biology

Volume / Issue

  • 167 / 2

Start / End Page

  • 203 - 207

PubMed ID

  • 15504907

Digital Object Identifier (DOI)

  • 10.1083/jcb.200408047