Interferon-γ secretion by t(9;22) acute lymphoblastic leukemia-derived dendritic cells.

Journal Article

Interferon (IFN)-γ plays an important role in immunity and anti-tumor activity. It is produced by lymphocytes, but was recently shown to be also produced by human myeloid dendritic cells (DCs). We have shown that human mature t(9;22) acute lymphoblastic leukemia-derived (ALL) DCs induced autologous cytotoxic T cell responses and therefore asked whether t(9;22) ALL-DC secreted IFN-γ. IFN-γ varied among three cell line-derived ALL-DCs; median production from seven patient ALL-DCs was 3450 pg/ml (range 1450-8675). IFN-γ production was dependent on maturation of ALL-DCs. This is the first demonstration of IFN-γ production by t(9;22) ALL-DCs.

Full Text

Duke Authors

Cited Authors

  • Brady, MT; Lee, J; Ferrone, S; Wang, ES; Wetzler, M

Published Date

  • February 2011

Published In

Volume / Issue

  • 35 / 2

Start / End Page

  • 275 - 277

PubMed ID

  • 20943267

Pubmed Central ID

  • 20943267

Electronic International Standard Serial Number (EISSN)

  • 1873-5835

Digital Object Identifier (DOI)

  • 10.1016/j.leukres.2010.09.003


  • eng

Conference Location

  • England