Prevention of sudden death in patients with coronary artery disease: the Multicenter Unsustained Tachycardia Trial (MUSTT).

Journal Article (Journal Article)

This trial will significantly advance our understanding of the prognostic and therapeutic usefulness of electrophysiologic studies in patients with coronary artery disease. Several features of this trial are worth emphasizing. First, the protocol for performing programmed stimulation and serial drug testing is designed to mirror those currently in use by many practicing electrophysiologists. While practice patterns vary, the procedures used in the trial reflect what is considered "usual and standard" practice. Second, because half of the patients with inducible sustained ventricular tachycardia will be given no antiarrhythmic therapy, we will be able to ascertain the true risk of sudden death in this patient population without the influence of these agents. Third, this trial will assess the usefulness of a method of guiding antiarrhythmic therapy (electrophysiologic testing) to reduce mortality in this high-risk population. It will not evaluate the efficacy of a specific type of antiarrhythmic therapy.

Full Text

Duke Authors

Cited Authors

  • Buxton, AE; Fisher, JD; Josephson, ME; Lee, KL; Pryor, DB; Prystowsky, EN; Simson, MB; DiCarlo, L; Echt, DS; Packer, D

Published Date

  • 1993

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 215 - 226

PubMed ID

  • 8234775

International Standard Serial Number (ISSN)

  • 0033-0620

Digital Object Identifier (DOI)

  • 10.1016/0033-0620(93)90015-6


  • eng

Conference Location

  • United States