Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal.

Journal Article (Journal Article)

We have previously found the 5-HT3 receptor antagonist ondansetron to be useful in reducing cocaine self-administration and cocaine induced sensitization in rats when given during cocaine withdrawal. More recently we have found the combination of the dopamine agonist pergolide plus ondansetron, 3.5 h later, to reverse cocaine sensitization and associated changes in NMDA and AMPA receptors. Here we tested this drug combination in 1) a methamphetamine sensitization model and 2) a reinstatement model after intravenous methamphetamine self-administration using a nose-poke task. We found pergolide plus ondansetron given from days 3-7 of methamphetamine withdrawal to reverse methamphetamine induced sensitization and attenuate reinstatement. We hypothesize that pergolide may evoke a methamphetamine associated memory and that ondansetron can disrupt its reconsolidation. These data suggest that pergolide plus ondansetron treatment may be useful as a therapy to reduce relapse in methamphetamine abusers.

Full Text

Duke Authors

Cited Authors

  • Davidson, C; Gopalan, R; Ahn, C; Chen, Q; Mannelli, P; Patkar, AA; Weese, GD; Lee, TH; Ellinwood, EH

Published Date

  • June 22, 2007

Published In

Volume / Issue

  • 565 / 1-3

Start / End Page

  • 113 - 118

PubMed ID

  • 17408614

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/j.ejphar.2007.02.056


  • eng

Conference Location

  • Netherlands