Ondansetron, given during the acute cocaine withdrawal, attenuates oral cocaine self-administration.


Journal Article

We have previously shown that ondansetron, given 3.5 h after intravenous cocaine self-administration, can attenuate self-administration the following day. Here we tested ondansetron given either before or after a 14-h oral cocaine session in rats. Ondansetron (0.2 mg/kg sc) given 30 min before the cocaine session had no effect. However, when given 3.5 h after, ondansetron attenuated cocaine intake the following day while having no effect on water intake. Taken with our previous data in intravenous cocaine self-administration, we suggest that the acute cocaine withdrawal period may be an important treatment window and that ondansetron may be an effective cocaine abuse therapy.

Full Text

Cited Authors

  • Davidson, C; Lazarus, C; Lee, TH; Ellinwood, EH

Published Date

  • October 2004

Published In

Volume / Issue

  • 503 / 1-3

Start / End Page

  • 99 - 102

PubMed ID

  • 15496303

Pubmed Central ID

  • 15496303

Electronic International Standard Serial Number (EISSN)

  • 1879-0712

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/j.ejphar.2004.09.041


  • eng