The NK(1) receptor antagonist WIN51708 reduces sensitization after chronic cocaine.


Journal Article

We tested the tachykinin NK(1) receptor antagonist WIN51708 (17betahydroxy17alphaethynyl5alphaandrostanol[3,2b]pyrimido[1,2-a]benzimidazole) in a behavioral sensitization model. Rats were given 7 days of cocaine then 7 days of withdrawal to induce sensitization. Thereafter, another 7 days of cocaine with WIN51708 (2 mg/kg i.p.) given 3.5 h after each cocaine injection was given. WIN51708 reversed sensitization but had no effect on controls. NK(1) receptor antagonists may have use in stimulant abuse and schizophrenia treatment.

Full Text

Cited Authors

  • Davidson, C; Lee, TH; Ellinwood, EH

Published Date

  • September 2004

Published In

Volume / Issue

  • 499 / 3

Start / End Page

  • 355 - 356

PubMed ID

  • 15381058

Pubmed Central ID

  • 15381058

Electronic International Standard Serial Number (EISSN)

  • 1879-0712

International Standard Serial Number (ISSN)

  • 1879-0712

Digital Object Identifier (DOI)

  • 10.1016/j.ejphar.2004.08.006


  • eng