Technique for the continuous infusion of high doses of cocaine by osmotic minipump.


Journal Article

The present article describes a procedure for modifying osmotic minipumps to avoid the local, toxic, necrotic effects of high concentrations of drug at the exit portal during the chronic, continuous infusion of cocaine. The present procedure eliminates the occurrence of necrotic skin lesions otherwise produced by SC administration of cocaine and/or other vasoconstrictive agents. The method of administration will therefore be useful for administration of other chronic drug regimens.

Full Text

Cited Authors

  • Joyner, C; King, G; Lee, TH; Ellinwood, EH

Published Date

  • April 1993

Published In

Volume / Issue

  • 44 / 4

Start / End Page

  • 971 - 973

PubMed ID

  • 8469707

Pubmed Central ID

  • 8469707

Electronic International Standard Serial Number (EISSN)

  • 1873-5177

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(93)90033-p


  • eng