In vitro extracellular recording from nigral dopamine neurons following continuous d-amphetamine infusion.


Journal Article

Single nigral dopamine neurons were extracellularly recorded in vitro after withdrawal from continuous d-amphetamine sulfate infusion (5.0 mg/kg per day for 7 days via subcutaneous osmotic minipumps). Seven days after withdrawal, the dopamine neurons were supersensitive to impulse-inhibition by dopamine. This increased sensitivity suggests a supersensitivity of soma/dendritic autoreceptors on these neurons, as we previously hypothesized based on a supersensitivity to intravenous apomorphine. In contrast to the day 7, the withdrawal day 1 was associated with a normosensitivity to dopamine, suggesting that the apomorphine subsensitivity observed in vivo on this day may be secondary to non-autoreceptor changes.

Full Text

Cited Authors

  • Lee, TH; Ellinwood, EH; Zhang, H

Published Date

  • February 1993

Published In

Volume / Issue

  • 232 / 1

Start / End Page

  • 125 - 129

PubMed ID

  • 8458391

Pubmed Central ID

  • 8458391

Electronic International Standard Serial Number (EISSN)

  • 1879-0712

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(93)90737-3


  • eng