Clomiphene blocks the effect of intravenous estradiol on the firing rate of rat nigral dopamine neurons.


Journal Article

Intravenous 17-beta-estradiol (BETA) has a potent, stereo-specific, and rapid effect on dopamine (DA) neuron firing rate in the substantia nigra compacta (SNC). Our data demonstrate that immediate intravenous pretreatment with the anti-estrogen clomiphene (CLOM) blocks the action of subsequent intravenous BETA administration. Our results provide further physiologic evidence for membrane-bound estradiol (E2) receptors within the rat brain.

Full Text

Cited Authors

  • McCall, WV; Ellinwood, EH; Nishita, JK; Lee, TH

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 60 / 1

Start / End Page

  • 141 - 144

PubMed ID

  • 3381008

Pubmed Central ID

  • 3381008

International Standard Serial Number (ISSN)

  • 0034-5164


  • eng