Systematic review of 99m Tc human serum albumin and 99m Tc sulfur colloid studies of sentinel lymph node biopsy of cutaneous melanoma of the head and neck


Conference Paper

Introduction: Sentinel lymph node biopsy (SLNB) of head and neck melanoma presents a technical challenge due to the multiplicity of basins and variable lymph node drainage. Radiotracer size and particulate nature determines speed of lymphatic drainage into nodal basins, as well as nodal uptake and retention. Human serum albumin (HSA) and sulfur colloid (SC) are commonly used radiotracers with divergent chemical characteristics. Results: Eligibility criteria were met for 26 studies (n=2257), 7 prospective and 19 retrospective. Of these, 8 studies (n=422) used HSA and 18 studies (n=1835) used SC. The identification rates of sentinel nodes for HSA and SC were 91.7% and 97.5%, respectively. The false negative rate was 12.5% and 12.2% in HSA and SC, respectively. The median post-test probability negative for nodal recurrence and for total recurrence was 3.9% and 12.6%, and 2.1% and 11.6%, respectively, for HSA and SC. Conclusion Although HSA and SC have different intrinsic chemical properties, both are efficacious for use in SLNB of cutaneous melanoma of the head and neck.

Full Text

Duke Authors

Cited Authors

  • De Rosa, N; Lyman, GH; Silbermins, D; Valsecchi, ME; Wong, S; Pruitt, SK; Lee, WT

Published Date

  • July 11, 2011

Published In

Volume / Issue

  • 121 / SUPPL. 4

Electronic International Standard Serial Number (EISSN)

  • 1531-4995

International Standard Serial Number (ISSN)

  • 0023-852X

Digital Object Identifier (DOI)

  • 10.1002/lary.21983

Citation Source

  • Scopus