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Science Signaling Podcast: 20 November 2012

Publication ,  Journal Article
Lefkowitz, RJ; VanHook, AM
Published in: Science Signaling
November 20, 2012

This Podcast features an interview with Robert Lefkowitz, corecipient of this year's Nobel Prize in Chemistry. Lefkowitz has been studying the function of G protein-coupled receptors (GPCRs) for 40 years, and his laboratory has made many important contributions to our current understanding of GPCR structure and function. GPCRs are integral membrane proteins with seven transmembrane- spanning domains. The extracellular portions of the receptors bind to ligands outside the cell, and the intracellular portions of these receptors transduce signaling. GPCRs control many different aspects of cell biology and participate in the regulation of many physiological processes. A large percentage of drugs in use today target GPCRs or their associated signal transduction partners. Lefkowitz discusses GPCR function and specificity, his role in this field of research, and future challenges.

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Published In

Science Signaling

DOI

EISSN

1937-9145

ISSN

1945-0877

Publication Date

November 20, 2012

Volume

5

Issue

251

Related Subject Headings

  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lefkowitz, R. J., & VanHook, A. M. (2012). Science Signaling Podcast: 20 November 2012. Science Signaling, 5(251). https://doi.org/10.1126/scisignal.2003756
Lefkowitz, R. J., and A. M. VanHook. “Science Signaling Podcast: 20 November 2012.” Science Signaling 5, no. 251 (November 20, 2012). https://doi.org/10.1126/scisignal.2003756.
Lefkowitz RJ, VanHook AM. Science Signaling Podcast: 20 November 2012. Science Signaling. 2012 Nov 20;5(251).
Lefkowitz, R. J., and A. M. VanHook. “Science Signaling Podcast: 20 November 2012.” Science Signaling, vol. 5, no. 251, Nov. 2012. Scopus, doi:10.1126/scisignal.2003756.
Lefkowitz RJ, VanHook AM. Science Signaling Podcast: 20 November 2012. Science Signaling. 2012 Nov 20;5(251).

Published In

Science Signaling

DOI

EISSN

1937-9145

ISSN

1945-0877

Publication Date

November 20, 2012

Volume

5

Issue

251

Related Subject Headings

  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology