Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.

Journal Article (Review)

Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors--including those relevant to the Hedgehog, Wnt, Notch, and TGFbeta pathways--and downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of arrestins in many discrete developmental signaling events suggests an indispensable role for these multifaceted molecular scaffolds.

Full Text

Duke Authors

Cited Authors

  • Kovacs, JJ; Hara, MR; Davenport, CL; Kim, J; Lefkowitz, RJ

Published Date

  • October 2009

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 443 - 458

PubMed ID

  • 19853559

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2009.09.011

Language

  • eng

Conference Location

  • United States