Crystallizing thinking about the beta2-adrenergic receptor.

Journal Article (Journal Article)

Two recently determined crystal structures of the human beta2-adrenergic receptor (beta2AR) provide a long-awaited advance in the field of G protein-coupled receptor research. The beta2AR is only the second member of this, the largest family of receptors encoded in the human genome, whose structure has been solved. It follows structures of rhodopsin that were determined previously. Here we set these developments in historical context, discuss the daunting challenges that have been overcome, and appraise what has and has not been learned.

Full Text

Duke Authors

Cited Authors

  • Shukla, AK; Sun, J-P; Lefkowitz, RJ

Published Date

  • May 2008

Published In

Volume / Issue

  • 73 / 5

Start / End Page

  • 1333 - 1338

PubMed ID

  • 18239031

Electronic International Standard Serial Number (EISSN)

  • 1521-0111

Digital Object Identifier (DOI)

  • 10.1124/mol.108.045849


  • eng

Conference Location

  • United States