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Seven transmembrane receptors: a brief personal retrospective.

Publication ,  Journal Article
Lefkowitz, RJ
Published in: Biochim Biophys Acta
April 2007

Receptors have fascinated biologists for more than a century and they have fascinated me for the entirety of my own research career. The seven transmembrane receptors, also known as G protein coupled receptors, represent the largest of the several families of plasma membrane receptors, comprising more than a thousand genes and regulating virtually all known physiological processes in mammals. Moreover, they represent one of the commonest targets of currently used drugs. I have spent the entirety of my research career working on these receptors. Here I set down some personal reflections on the evolution of the field during the past 35 years, hanging the thread of the story on some of the work from my own laboratory.

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Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

April 2007

Volume

1768

Issue

4

Start / End Page

748 / 755

Location

Netherlands

Related Subject Headings

  • Receptors, G-Protein-Coupled
  • Physiology
  • Pharmacology
  • History, 20th Century
  • Animals
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 02 Physical Sciences
 

Citation

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Lefkowitz, R. J. (2007). Seven transmembrane receptors: a brief personal retrospective. Biochim Biophys Acta, 1768(4), 748–755. https://doi.org/10.1016/j.bbamem.2006.11.001
Lefkowitz, Robert J. “Seven transmembrane receptors: a brief personal retrospective.Biochim Biophys Acta 1768, no. 4 (April 2007): 748–55. https://doi.org/10.1016/j.bbamem.2006.11.001.
Lefkowitz RJ. Seven transmembrane receptors: a brief personal retrospective. Biochim Biophys Acta. 2007 Apr;1768(4):748–55.
Lefkowitz, Robert J. “Seven transmembrane receptors: a brief personal retrospective.Biochim Biophys Acta, vol. 1768, no. 4, Apr. 2007, pp. 748–55. Pubmed, doi:10.1016/j.bbamem.2006.11.001.
Lefkowitz RJ. Seven transmembrane receptors: a brief personal retrospective. Biochim Biophys Acta. 2007 Apr;1768(4):748–755.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

April 2007

Volume

1768

Issue

4

Start / End Page

748 / 755

Location

Netherlands

Related Subject Headings

  • Receptors, G-Protein-Coupled
  • Physiology
  • Pharmacology
  • History, 20th Century
  • Animals
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 02 Physical Sciences