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New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.

Publication ,  Journal Article
Lefkowitz, RJ; Rajagopal, K; Whalen, EJ
Published in: Mol Cell
December 8, 2006

beta-arrestins, originally discovered as molecules that bind to and desensitize the activated and phosphorylated form of the G protein-coupled beta2-adrenergic receptor (beta2-AR), have recently emerged as multifunctional adaptor/scaffold proteins that dynamically assemble a wide range of multiprotein complexes in response to stimulation of most seven-transmembrane receptors (7TMRs). These complexes mediate receptor signaling, trafficking, and degradation. Moreover, beta-arrestins are increasingly found to perform analogous functions for receptors from structurally diverse classes, including atypical 7TMRs such as frizzled and smoothened, the nicotinic cholinergic receptors, receptor tyrosine kinases, and cytokine receptors, thereby regulating a growing list of cellular processes such as chemotaxis, apoptosis, and metastasis.

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Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

December 8, 2006

Volume

24

Issue

5

Start / End Page

643 / 652

Location

United States

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Protein Conformation
  • Models, Molecular
  • Humans
  • Developmental Biology
  • Arrestins
  • Animals
  • 42 Health sciences
 

Citation

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ICMJE
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Lefkowitz, R. J., Rajagopal, K., & Whalen, E. J. (2006). New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. Mol Cell, 24(5), 643–652. https://doi.org/10.1016/j.molcel.2006.11.007
Lefkowitz, Robert J., Keshava Rajagopal, and Erin J. Whalen. “New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.Mol Cell 24, no. 5 (December 8, 2006): 643–52. https://doi.org/10.1016/j.molcel.2006.11.007.
Lefkowitz RJ, Rajagopal K, Whalen EJ. New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. Mol Cell. 2006 Dec 8;24(5):643–52.
Lefkowitz, Robert J., et al. “New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.Mol Cell, vol. 24, no. 5, Dec. 2006, pp. 643–52. Pubmed, doi:10.1016/j.molcel.2006.11.007.
Lefkowitz RJ, Rajagopal K, Whalen EJ. New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. Mol Cell. 2006 Dec 8;24(5):643–652.
Journal cover image

Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

December 8, 2006

Volume

24

Issue

5

Start / End Page

643 / 652

Location

United States

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Protein Conformation
  • Models, Molecular
  • Humans
  • Developmental Biology
  • Arrestins
  • Animals
  • 42 Health sciences