GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling.

Journal Article (Journal Article;Review)

Stimulation of cell-surface seven-transmembrane receptors (7TMRs) elicits biological responses to a wide range of extracellular signals, including many hormones. Classically, heterotrimeric GTP-binding proteins (G proteins) are recruited to the activated conformation of 7TMRs. Only two other families of protein have this remarkable characteristic: G-protein-coupled receptor kinases and beta-arrestins. These two protein families have long been known to have a central and coordinated role in the "desensitization" of G protein activation by 7TMRs. In addition, G-protein-coupled receptor kinases and beta-arrestins are involved in an increasing number of interactions with non-receptor proteins, broadening the variety of their cellular functions. These newly appreciated attributes of these two families of protein highlight their unique ability to coordinate the various aspects of 7TMR functions.

Full Text

Duke Authors

Cited Authors

  • Reiter, E; Lefkowitz, RJ

Published Date

  • 2006

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 159 - 165

PubMed ID

  • 16595179

International Standard Serial Number (ISSN)

  • 1043-2760

Digital Object Identifier (DOI)

  • 10.1016/j.tem.2006.03.008


  • eng

Conference Location

  • United States