beta-arrestins: traffic cops of cell signaling.

Published

Journal Article (Review)

Once thought to function only in the desensitization of seven membrane spanning receptors (7MSRs), the ubiquitous beta-arrestin molecules are increasingly appreciated to play important roles in the endocytosis and signaling of these receptors. These functions reflect the ability of the beta-arrestins to bind an ever-growing list of signaling and endocytic elements, often in an agonist-dependent fashion. One heavily studied system is that leading to MAP kinase activation via beta-arrestin-mediated scaffolding of these pathways in a receptor-dependent fashion. The beta-arrestins are also found to be involved in the regulation of novel receptor systems, such as Frizzled and TGFbeta receptors.

Full Text

Duke Authors

Cited Authors

  • Lefkowitz, RJ; Whalen, EJ

Published Date

  • April 2004

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 162 - 168

PubMed ID

  • 15196559

Pubmed Central ID

  • 15196559

Electronic International Standard Serial Number (EISSN)

  • 1879-0410

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/j.ceb.2004.01.001

Language

  • eng