Regulation of G protein-coupled receptor signaling by scaffold proteins.

Journal Article (Journal Article;Review)

The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric G proteins, which can activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors can also interact with a number of cytoplasmic scaffold proteins, which can link the receptors to various signaling intermediates and intracellular effectors. The multicomponent nature of G protein-coupled receptor signaling pathways makes them ideally suited for regulation by scaffold proteins. This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues.

Full Text

Duke Authors

Cited Authors

  • Hall, RA; Lefkowitz, RJ

Published Date

  • October 18, 2002

Published In

Volume / Issue

  • 91 / 8

Start / End Page

  • 672 - 680

PubMed ID

  • 12386143

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

Digital Object Identifier (DOI)

  • 10.1161/01.res.0000037000.74258.03


  • eng

Conference Location

  • United States