Regulation of G protein-coupled receptor signaling by scaffold proteins.
Published
Journal Article (Review)
The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric G proteins, which can activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors can also interact with a number of cytoplasmic scaffold proteins, which can link the receptors to various signaling intermediates and intracellular effectors. The multicomponent nature of G protein-coupled receptor signaling pathways makes them ideally suited for regulation by scaffold proteins. This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues.
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Duke Authors
Cited Authors
- Hall, RA; Lefkowitz, RJ
Published Date
- October 18, 2002
Published In
Volume / Issue
- 91 / 8
Start / End Page
- 672 - 680
PubMed ID
- 12386143
Pubmed Central ID
- 12386143
Electronic International Standard Serial Number (EISSN)
- 1524-4571
Digital Object Identifier (DOI)
- 10.1161/01.res.0000037000.74258.03
Language
- eng
Conference Location
- United States