Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.

Published

Journal Article

Catecholamines signal through the beta2-adrenergic receptor by promoting production of the second messenger adenosine 3',5'-monophosphate (cAMP). The magnitude of this signal is restricted by desensitization of the receptors through their binding to beta-arrestins and by cAMP degradation by phosphodiesterase (PDE) enzymes. We show that beta-arrestins coordinate both processes by recruiting PDEs to activated beta2-adrenergic receptors in the plasma membrane of mammalian cells. In doing so, the beta-arrestins limit activation of membrane-associated cAMP-activated protein kinase by simultaneously slowing the rate of cAMP production through receptor desensitization and increasing the rate of its degradation at the membrane.

Full Text

Duke Authors

Cited Authors

  • Perry, SJ; Baillie, GS; Kohout, TA; McPhee, I; Magiera, MM; Ang, KL; Miller, WE; McLean, AJ; Conti, M; Houslay, MD; Lefkowitz, RJ

Published Date

  • October 2002

Published In

Volume / Issue

  • 298 / 5594

Start / End Page

  • 834 - 836

PubMed ID

  • 12399592

Pubmed Central ID

  • 12399592

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1074683

Language

  • eng