Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Journal Article (Journal Article)
Catecholamines signal through the beta2-adrenergic receptor by promoting production of the second messenger adenosine 3',5'-monophosphate (cAMP). The magnitude of this signal is restricted by desensitization of the receptors through their binding to beta-arrestins and by cAMP degradation by phosphodiesterase (PDE) enzymes. We show that beta-arrestins coordinate both processes by recruiting PDEs to activated beta2-adrenergic receptors in the plasma membrane of mammalian cells. In doing so, the beta-arrestins limit activation of membrane-associated cAMP-activated protein kinase by simultaneously slowing the rate of cAMP production through receptor desensitization and increasing the rate of its degradation at the membrane.
Full Text
Duke Authors
Cited Authors
- Perry, SJ; Baillie, GS; Kohout, TA; McPhee, I; Magiera, MM; Ang, KL; Miller, WE; McLean, AJ; Conti, M; Houslay, MD; Lefkowitz, RJ
Published Date
- October 25, 2002
Published In
Volume / Issue
- 298 / 5594
Start / End Page
- 834 - 836
PubMed ID
- 12399592
Electronic International Standard Serial Number (EISSN)
- 1095-9203
Digital Object Identifier (DOI)
- 10.1126/science.1074683
Language
- eng
Conference Location
- United States