Arresting developments in heptahelical receptor signaling and regulation.
Journal Article (Journal Article;Review)
It is well established that the function of most heptahelical receptors (seven-transmembrane-span receptors; 7TMRs) is tightly regulated by the desensitizing actions of arrestins. Desensitization is the waning of 7TMR-mediated signals after prolonged exposure to agonist and occurs when arrestins bind to agonist-occupied and phosphorylated receptors, uncoupling the receptors from G proteins and preventing further signaling. Recently, there has been a marked shift in the focus of research into arrestin function because it has become clear that they not only prevent signaling from 7TMRs but also initiate and direct new signals from the very 7TMRs that they desensitize.
Full Text
Duke Authors
Cited Authors
- Perry, SJ; Lefkowitz, RJ
Published Date
- March 2002
Published In
Volume / Issue
- 12 / 3
Start / End Page
- 130 - 138
PubMed ID
- 11859025
International Standard Serial Number (ISSN)
- 0962-8924
Digital Object Identifier (DOI)
- 10.1016/s0962-8924(01)02239-5
Language
- eng
Conference Location
- England