Arresting developments in heptahelical receptor signaling and regulation.

Journal Article (Journal Article;Review)

It is well established that the function of most heptahelical receptors (seven-transmembrane-span receptors; 7TMRs) is tightly regulated by the desensitizing actions of arrestins. Desensitization is the waning of 7TMR-mediated signals after prolonged exposure to agonist and occurs when arrestins bind to agonist-occupied and phosphorylated receptors, uncoupling the receptors from G proteins and preventing further signaling. Recently, there has been a marked shift in the focus of research into arrestin function because it has become clear that they not only prevent signaling from 7TMRs but also initiate and direct new signals from the very 7TMRs that they desensitize.

Full Text

Duke Authors

Cited Authors

  • Perry, SJ; Lefkowitz, RJ

Published Date

  • March 2002

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 130 - 138

PubMed ID

  • 11859025

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/s0962-8924(01)02239-5


  • eng

Conference Location

  • England