Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener.

Published online

Journal Article (Review)

Recent data suggest that internalized receptor and arrestin complexes are actively involved in signal transduction. Miller and Lefkowitz discuss evidence from the Drosophila visual system that suggests that intracellular rhodopsin and arrestin2 complexes induce apoptosis. Experiments with activated mammalian G protein-coupled receptor and arrestin complexes point to a mechanism by which proliferative or proapoptotic signals can be mediated largely independent from G protein activation.

Full Text

Duke Authors

Cited Authors

  • Miller, WE; Lefkowitz, RJ

Published Date

  • February 13, 2001

Published In

Volume / Issue

  • 2001 / 69

Start / End Page

  • pe1 -

PubMed ID

  • 11752639

Pubmed Central ID

  • 11752639

Electronic International Standard Serial Number (EISSN)

  • 1525-8882

Digital Object Identifier (DOI)

  • 10.1126/stke.2001.69.pe1

Language

  • eng

Conference Location

  • United States