Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

Published

Journal Article (Review)

Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.

Full Text

Duke Authors

Cited Authors

  • Luttrell, LM; Daaka, Y; Lefkowitz, RJ

Published Date

  • April 1999

Published In

Volume / Issue

  • 11 / 2

Start / End Page

  • 177 - 183

PubMed ID

  • 10209148

Pubmed Central ID

  • 10209148

Electronic International Standard Serial Number (EISSN)

  • 1879-0410

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/s0955-0674(99)80023-4

Language

  • eng