Gene transfer strategies for augmenting cardiac function.


Journal Article

Recent transgenic as well as gene-targeted animal models have greatly increased our understanding of the molecular mechanisms of normal and compromised heart function. These studies have raised the possibility of using somatic gene transfer as a means for improving cardiac function. DNA transfer to a significant portion of the myocardium has thus far been difficult to accomplish. This review describes current efforts to achieve myocardial gene transfer in several model systems, with particular emphasis placed on adenovirus-mediated gene delivery, its possibilities, and current limitations. (Trend Cardiovasc Med 1997;7:145-150). © 1997, Elsevier Science Inc.

Full Text

Duke Authors

Cited Authors

  • Peppel, K; Koch, WJ; Lefkowitz, RJ

Published Date

  • July 1997

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 145 - 150

PubMed ID

  • 21235878

Pubmed Central ID

  • 21235878

International Standard Serial Number (ISSN)

  • 1050-1738

Digital Object Identifier (DOI)

  • 10.1016/S1050-1738(97)00028-5


  • eng

Conference Location

  • United States