Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.

Journal Article (Journal Article;Review)

In disease states such as heart failure, catecholamines released from sympathetic nerve endings and the adrenal medulla play a central role in the adaptive and maladaptive physiological response to altered tissue perfusion. G protein-coupled receptors are importantly involved in myocardial growth and the regulation of contractility. The adrenergic receptors themselves are regulated by a set of specific kinases, termed the G protein-coupled receptor kinases. The study of complex systems in vivo has recently been advanced by the development of transgenic and gene-targeted "knockout" mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac function is an extremely powerful strategy for studying the regulation of myocardial contractility in normal animals and in models of disease states. The purpose of this review is to summarize current knowledge about the regulation of cardiovascular homeostasis involving signaling pathways through stimulation of adrenergic receptors.

Full Text

Duke Authors

Cited Authors

  • Rockman, HA; Koch, WJ; Lefkowitz, RJ

Published Date

  • April 1997

Published In

Volume / Issue

  • 272 / 4 Pt 2

Start / End Page

  • H1553 - H1559

PubMed ID

  • 9139936

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.1997.272.4.H1553


  • eng

Conference Location

  • United States