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Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.

Publication ,  Journal Article
Rockman, HA; Koch, WJ; Lefkowitz, RJ
Published in: Am J Physiol
April 1997

In disease states such as heart failure, catecholamines released from sympathetic nerve endings and the adrenal medulla play a central role in the adaptive and maladaptive physiological response to altered tissue perfusion. G protein-coupled receptors are importantly involved in myocardial growth and the regulation of contractility. The adrenergic receptors themselves are regulated by a set of specific kinases, termed the G protein-coupled receptor kinases. The study of complex systems in vivo has recently been advanced by the development of transgenic and gene-targeted "knockout" mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac function is an extremely powerful strategy for studying the regulation of myocardial contractility in normal animals and in models of disease states. The purpose of this review is to summarize current knowledge about the regulation of cardiovascular homeostasis involving signaling pathways through stimulation of adrenergic receptors.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

April 1997

Volume

272

Issue

4 Pt 2

Start / End Page

H1553 / H1559

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Adrenergic, beta-3
  • Receptors, Adrenergic, beta-2
  • Receptors, Adrenergic, beta-1
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha-2
  • Receptors, Adrenergic, alpha-1
  • Receptors, Adrenergic
  • Mice, Transgenic
  • Mice, Knockout
 

Citation

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Rockman, H. A., Koch, W. J., & Lefkowitz, R. J. (1997). Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol, 272(4 Pt 2), H1553–H1559. https://doi.org/10.1152/ajpheart.1997.272.4.H1553
Rockman, H. A., W. J. Koch, and R. J. Lefkowitz. “Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.Am J Physiol 272, no. 4 Pt 2 (April 1997): H1553–59. https://doi.org/10.1152/ajpheart.1997.272.4.H1553.
Rockman HA, Koch WJ, Lefkowitz RJ. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol. 1997 Apr;272(4 Pt 2):H1553–9.
Rockman, H. A., et al. “Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.Am J Physiol, vol. 272, no. 4 Pt 2, Apr. 1997, pp. H1553–59. Pubmed, doi:10.1152/ajpheart.1997.272.4.H1553.
Rockman HA, Koch WJ, Lefkowitz RJ. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol. 1997 Apr;272(4 Pt 2):H1553–H1559.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

April 1997

Volume

272

Issue

4 Pt 2

Start / End Page

H1553 / H1559

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Adrenergic, beta-3
  • Receptors, Adrenergic, beta-2
  • Receptors, Adrenergic, beta-1
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha-2
  • Receptors, Adrenergic, alpha-1
  • Receptors, Adrenergic
  • Mice, Transgenic
  • Mice, Knockout