Skip to main content

Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region.

Publication ,  Journal Article
Collins, S; Ostrowski, J; Lefkowitz, RJ
Published in: Biochim Biophys Acta
February 20, 1993

We present 3.1 kb of the nucleotide sequence from the 5'-flanking region of the human beta 1-adrenergic receptor gene. The first 1.0 kb upstream from the translational start site is composed of 72% G + C residues. The sequence was analyzed for the presence of transcriptional regulatory elements and contains putative thyroid hormone, glucocorticoid hormone and cAMP response elements. These putative hormone response elements support physiological evidence that thyroid and glucocorticoid hormones regulate beta 1AR function by affecting receptor expression in tissues such as heart and adipose, where beta 1-adrenergic receptors are important regulators of heart rate and lipolysis, respectively.

Duke Scholars

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

February 20, 1993

Volume

1172

Issue

1-2

Start / End Page

171 / 174

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • Sequence Homology, Nucleic Acid
  • Restriction Mapping
  • Regulatory Sequences, Nucleic Acid
  • Receptors, Adrenergic, beta
  • Promoter Regions, Genetic
  • Polymerase Chain Reaction
  • Oligodeoxyribonucleotides
  • Molecular Sequence Data
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Collins, S., Ostrowski, J., & Lefkowitz, R. J. (1993). Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region. Biochim Biophys Acta, 1172(1–2), 171–174. https://doi.org/10.1016/0167-4781(93)90287-n
Collins, S., J. Ostrowski, and R. J. Lefkowitz. “Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region.Biochim Biophys Acta 1172, no. 1–2 (February 20, 1993): 171–74. https://doi.org/10.1016/0167-4781(93)90287-n.
Collins S, Ostrowski J, Lefkowitz RJ. Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region. Biochim Biophys Acta. 1993 Feb 20;1172(1–2):171–4.
Collins, S., et al. “Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region.Biochim Biophys Acta, vol. 1172, no. 1–2, Feb. 1993, pp. 171–74. Pubmed, doi:10.1016/0167-4781(93)90287-n.
Collins S, Ostrowski J, Lefkowitz RJ. Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region. Biochim Biophys Acta. 1993 Feb 20;1172(1–2):171–174.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

February 20, 1993

Volume

1172

Issue

1-2

Start / End Page

171 / 174

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • Sequence Homology, Nucleic Acid
  • Restriction Mapping
  • Regulatory Sequences, Nucleic Acid
  • Receptors, Adrenergic, beta
  • Promoter Regions, Genetic
  • Polymerase Chain Reaction
  • Oligodeoxyribonucleotides
  • Molecular Sequence Data
  • Humans