Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region.
Journal Article (Journal Article)
We present 3.1 kb of the nucleotide sequence from the 5'-flanking region of the human beta 1-adrenergic receptor gene. The first 1.0 kb upstream from the translational start site is composed of 72% G + C residues. The sequence was analyzed for the presence of transcriptional regulatory elements and contains putative thyroid hormone, glucocorticoid hormone and cAMP response elements. These putative hormone response elements support physiological evidence that thyroid and glucocorticoid hormones regulate beta 1AR function by affecting receptor expression in tissues such as heart and adipose, where beta 1-adrenergic receptors are important regulators of heart rate and lipolysis, respectively.
Full Text
Duke Authors
Cited Authors
- Collins, S; Ostrowski, J; Lefkowitz, RJ
Published Date
- February 20, 1993
Published In
Volume / Issue
- 1172 / 1-2
Start / End Page
- 171 - 174
PubMed ID
- 8382527
International Standard Serial Number (ISSN)
- 0006-3002
Digital Object Identifier (DOI)
- 10.1016/0167-4781(93)90287-n
Language
- eng
Conference Location
- Netherlands