Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region.

Published

Journal Article

We present 3.1 kb of the nucleotide sequence from the 5'-flanking region of the human beta 1-adrenergic receptor gene. The first 1.0 kb upstream from the translational start site is composed of 72% G + C residues. The sequence was analyzed for the presence of transcriptional regulatory elements and contains putative thyroid hormone, glucocorticoid hormone and cAMP response elements. These putative hormone response elements support physiological evidence that thyroid and glucocorticoid hormones regulate beta 1AR function by affecting receptor expression in tissues such as heart and adipose, where beta 1-adrenergic receptors are important regulators of heart rate and lipolysis, respectively.

Full Text

Duke Authors

Cited Authors

  • Collins, S; Ostrowski, J; Lefkowitz, RJ

Published Date

  • February 1993

Published In

Volume / Issue

  • 1172 / 1-2

Start / End Page

  • 171 - 174

PubMed ID

  • 8382527

Pubmed Central ID

  • 8382527

Electronic International Standard Serial Number (EISSN)

  • 1878-2434

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/0167-4781(93)90287-n

Language

  • eng