Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model.

Journal Article (Journal Article;Review)

Desensitization, the tendency of biological responses to wane over time despite the continuous presence of a stimulus of constant intensity, is observed in organisms as diverse as bacteria and mammals. Recently, new insights into the molecular mechanisms underlying these phenomena have emerged from the study of the receptors coupled to the ubiquitous second messenger-generating system adenylate cyclase. These mechanisms involve sequestration or down-regulation of the receptors from the cell surface as well as functionally significant covalent modifications of the receptors and/or guanine nucleotide regulatory proteins.

Full Text

Duke Authors

Cited Authors

  • Sibley, DR; Lefkowitz, RJ

Published Date

  • September 12, 1985

Published In

Volume / Issue

  • 317 / 6033

Start / End Page

  • 124 - 129

PubMed ID

  • 2993919

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/317124a0


  • eng

Conference Location

  • England