Clinical physiology of adrenergic receptor regulation.
Journal Article (Journal Article)
Radioligand binding studies now permit the direct investigation of the alpha- and beta-adrenergic receptors. The concentration of the receptors in cell membranes is modulated by a wide variety of physiological and pathophysiological variables and may be either increased or decreased in different conditions. Ligand binding techniques have also shed light on the ways in which the adrenergic receptors are coupled to other components of the hormone-sensitive adenylate cyclase system. This "coupling" is also a highly regulated step, control of which importantly influences catecholamine and sensitivity of tissues.
Full Text
Duke Authors
Cited Authors
- Lefkowitz, RJ
Published Date
- July 1982
Published In
Volume / Issue
- 243 / 1
Start / End Page
- E43 - E47
PubMed ID
- 6124130
International Standard Serial Number (ISSN)
- 0002-9513
Digital Object Identifier (DOI)
- 10.1152/ajpendo.1982.243.1.E43
Language
- eng
Conference Location
- United States