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Clinical physiology of adrenergic receptor regulation.

Publication ,  Journal Article
Lefkowitz, RJ
Published in: Am J Physiol
July 1982

Radioligand binding studies now permit the direct investigation of the alpha- and beta-adrenergic receptors. The concentration of the receptors in cell membranes is modulated by a wide variety of physiological and pathophysiological variables and may be either increased or decreased in different conditions. Ligand binding techniques have also shed light on the ways in which the adrenergic receptors are coupled to other components of the hormone-sensitive adenylate cyclase system. This "coupling" is also a highly regulated step, control of which importantly influences catecholamine and sensitivity of tissues.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

July 1982

Volume

243

Issue

1

Start / End Page

E43 / E47

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Kinetics
  • Humans
  • Guanosine Triphosphate
  • Guanosine Diphosphate
  • Cardiovascular System & Hematology
  • Animals
  • Adrenergic beta-Antagonists
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lefkowitz, R. J. (1982). Clinical physiology of adrenergic receptor regulation. Am J Physiol, 243(1), E43–E47. https://doi.org/10.1152/ajpendo.1982.243.1.E43
Lefkowitz, R. J. “Clinical physiology of adrenergic receptor regulation.Am J Physiol 243, no. 1 (July 1982): E43–47. https://doi.org/10.1152/ajpendo.1982.243.1.E43.
Lefkowitz RJ. Clinical physiology of adrenergic receptor regulation. Am J Physiol. 1982 Jul;243(1):E43–7.
Lefkowitz, R. J. “Clinical physiology of adrenergic receptor regulation.Am J Physiol, vol. 243, no. 1, July 1982, pp. E43–47. Pubmed, doi:10.1152/ajpendo.1982.243.1.E43.
Lefkowitz RJ. Clinical physiology of adrenergic receptor regulation. Am J Physiol. 1982 Jul;243(1):E43–E47.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

July 1982

Volume

243

Issue

1

Start / End Page

E43 / E47

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Kinetics
  • Humans
  • Guanosine Triphosphate
  • Guanosine Diphosphate
  • Cardiovascular System & Hematology
  • Animals
  • Adrenergic beta-Antagonists