Clinical physiology of adrenergic receptor regulation

Published

Journal Article

Radioligand binding studies now permit the direct investigation of the α- and β-adrenergic receptors. The concentration of the receptors in cell membranes is modulated by a wide variety of physiological and pathophysiological variables and may be either increased or decreased in different conditions. Ligand binding techniques have also shed light on the ways in which the adrenergic receptors are coupled to other components of the hormone-sensitive adenylate cyclase system. This 'coupling' is also a highly regulated step, control of which importantly influences catecholamine sensitivity of tissues.

Duke Authors

Cited Authors

  • Lefkowitz, RJ

Published Date

  • January 1, 1982

Published In

Volume / Issue

  • 6 / 1

International Standard Serial Number (ISSN)

  • 0193-1849

Citation Source

  • Scopus