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Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia.

Publication ,  Journal Article
Mukherjee, A; Wong, TM; Buja, LM; Lefkowitz, RJ; Willerson, JT
Published in: J Clin Invest
November 1979

Experimental myocardial ischemia produced in dogs by proximal left anterior descending coronary artery ligation is accompanied by relatively rapid (1 h) increases in the number of (-) [3H]dihydroalprenolol binding sites without changing their dissociation constants in ischemic left ventricular tissue. The changes, persist for at least 8 h and are accompanied by marked decreases in myocardial tissue ischemic region norepinephrine content. In contrast, in the same canine model 1 h of proximal left anterior descending coronary artery ligation did not result in a significant change in the number of [3H]quinuclidynl benzilate binding sites of their dissociation constants. However, the number of [3H]quinuclidynl benzilate binding sites (muscarinic cholinergic receptors) are 50--70% greater than (-) [3H]dihydroalprenolol binding sites (beta adrenergic receptors) in canine left ventricular tissue. Thus, the data suggest that proximal left anterior descending coronary artery occlusion for 1 h significantly increases the number of beta adrenergic receptors in ischemic left ventricular tissue without changing the number of muscarinic cholinergic receptors. Whether the ischemia-produced increase in cardiac beta-receptor content is causally related to increased cyclic AMP levels that develop in ischemic tissue and/or an etiologic factor in arrhythmias originating from ischemic myocardial tissue will have to be determined in additional studies.

Duke Scholars

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

November 1979

Volume

64

Issue

5

Start / End Page

1423 / 1428

Location

United States

Related Subject Headings

  • Receptors, Muscarinic
  • Receptors, Cholinergic
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Quinuclidinyl Benzilate
  • Norepinephrine
  • Myocardium
  • Male
  • Ligation
  • Immunology
 

Citation

APA
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Mukherjee, A., Wong, T. M., Buja, L. M., Lefkowitz, R. J., & Willerson, J. T. (1979). Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia. J Clin Invest, 64(5), 1423–1428. https://doi.org/10.1172/JCI109600
Mukherjee, A., T. M. Wong, L. M. Buja, R. J. Lefkowitz, and J. T. Willerson. “Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia.J Clin Invest 64, no. 5 (November 1979): 1423–28. https://doi.org/10.1172/JCI109600.
Mukherjee A, Wong TM, Buja LM, Lefkowitz RJ, Willerson JT. Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia. J Clin Invest. 1979 Nov;64(5):1423–8.
Mukherjee, A., et al. “Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia.J Clin Invest, vol. 64, no. 5, Nov. 1979, pp. 1423–28. Pubmed, doi:10.1172/JCI109600.
Mukherjee A, Wong TM, Buja LM, Lefkowitz RJ, Willerson JT. Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia. J Clin Invest. 1979 Nov;64(5):1423–1428.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

November 1979

Volume

64

Issue

5

Start / End Page

1423 / 1428

Location

United States

Related Subject Headings

  • Receptors, Muscarinic
  • Receptors, Cholinergic
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Quinuclidinyl Benzilate
  • Norepinephrine
  • Myocardium
  • Male
  • Ligation
  • Immunology