Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma.

Journal Article (Journal Article)

Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma.

Full Text

Duke Authors

Cited Authors

  • Lefkowitz, RJ; Roth, J; Pastan, I

Published Date

  • November 6, 1970

Published In

Volume / Issue

  • 170 / 3958

Start / End Page

  • 633 - 635

PubMed ID

  • 4319388

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.170.3958.633


  • eng

Conference Location

  • United States