Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes
We investigated whether early hematoma or edema volumes could explain the adverse association between APOE ε4 and survival in intracerebral hemorrhage. Among 102 patients, ε4 carriers had a higher mortality rate than non-ε4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p < 0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p < 0.01, but these were not associated with ε4 after adjusting for race, age, and type of hemorrhage.
McCarron, MO; Hoffmann, KL; DeLong, DM; Gray, L; Saunders, AM; Alberts, MJ
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