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Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.

Publication ,  Journal Article
McCarron, MO; Hoffmann, KL; DeLong, DM; Gray, L; Saunders, AM; Alberts, MJ
Published in: Neurology
December 10, 1999

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p<0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p<0.01), but these were not associated with epsilon4 after adjusting for race, age, and type of hemorrhage.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

December 10, 1999

Volume

53

Issue

9

Start / End Page

2176 / 2179

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Hematoma
  • Genotype
  • Genetic Carrier Screening
  • Gene Frequency
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McCarron, M. O., Hoffmann, K. L., DeLong, D. M., Gray, L., Saunders, A. M., & Alberts, M. J. (1999). Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes. Neurology, 53(9), 2176–2179. https://doi.org/10.1212/wnl.53.9.2176
McCarron, M. O., K. L. Hoffmann, D. M. DeLong, L. Gray, A. M. Saunders, and M. J. Alberts. “Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.Neurology 53, no. 9 (December 10, 1999): 2176–79. https://doi.org/10.1212/wnl.53.9.2176.
McCarron MO, Hoffmann KL, DeLong DM, Gray L, Saunders AM, Alberts MJ. Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes. Neurology. 1999 Dec 10;53(9):2176–9.
McCarron, M. O., et al. “Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.Neurology, vol. 53, no. 9, Dec. 1999, pp. 2176–79. Pubmed, doi:10.1212/wnl.53.9.2176.
McCarron MO, Hoffmann KL, DeLong DM, Gray L, Saunders AM, Alberts MJ. Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes. Neurology. 1999 Dec 10;53(9):2176–2179.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

December 10, 1999

Volume

53

Issue

9

Start / End Page

2176 / 2179

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Hematoma
  • Genotype
  • Genetic Carrier Screening
  • Gene Frequency