Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes

Journal Article

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE ε4 and survival in intracerebral hemorrhage. Among 102 patients, ε4 carriers had a higher mortality rate than non-ε4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p < 0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p < 0.01, but these were not associated with ε4 after adjusting for race, age, and type of hemorrhage.

Duke Authors

Cited Authors

  • McCarron, MO; Hoffmann, KL; DeLong, DM; Gray, L; Saunders, AM; Alberts, MJ

Published Date

  • 1999

Published In

Volume / Issue

  • 53 / 9

Start / End Page

  • 2176 - 2179

PubMed ID

  • 10599801

International Standard Serial Number (ISSN)

  • 0028-3878