The CERAD experience, Part VIII: Neuroimaging-neuropathology correlates of temporal lobe changes in Alzheimer's disease.
Published
Journal Article
We compared premortem neuroimaging findings with neuropathologic evidence of temporal lobe atrophy in 20 patients with Alzheimer's disease (AD) confirmed by autopsy. There were significant correlations between temporal horn enlargement observed by neuroimaging and hippocampal atrophy at autopsy, and between the overall cerebral atrophy severity on neuroimaging and scores on the Mini-Mental State Examination. This report confirms previous studies correlating temporal lobe atrophy on neuroimaging with a clinical diagnosis of AD, although more precise neuroimaging techniques are needed for use in multicenter studies of AD.
Full Text
Duke Authors
Cited Authors
- Davis, PC; Gearing, M; Gray, L; Mirra, SS; Morris, JC; Edland, SD; Lin, T; Heyman, A
Published Date
- January 1995
Published In
Volume / Issue
- 45 / 1
Start / End Page
- 178 - 179
PubMed ID
- 7824112
Pubmed Central ID
- 7824112
International Standard Serial Number (ISSN)
- 0028-3878
Digital Object Identifier (DOI)
- 10.1212/wnl.45.1.178
Language
- eng
Conference Location
- United States