The CERAD experience, Part VIII: Neuroimaging-neuropathology correlates of temporal lobe changes in Alzheimer's disease.


Journal Article

We compared premortem neuroimaging findings with neuropathologic evidence of temporal lobe atrophy in 20 patients with Alzheimer's disease (AD) confirmed by autopsy. There were significant correlations between temporal horn enlargement observed by neuroimaging and hippocampal atrophy at autopsy, and between the overall cerebral atrophy severity on neuroimaging and scores on the Mini-Mental State Examination. This report confirms previous studies correlating temporal lobe atrophy on neuroimaging with a clinical diagnosis of AD, although more precise neuroimaging techniques are needed for use in multicenter studies of AD.

Full Text

Duke Authors

Cited Authors

  • Davis, PC; Gearing, M; Gray, L; Mirra, SS; Morris, JC; Edland, SD; Lin, T; Heyman, A

Published Date

  • January 1995

Published In

Volume / Issue

  • 45 / 1

Start / End Page

  • 178 - 179

PubMed ID

  • 7824112

Pubmed Central ID

  • 7824112

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.45.1.178


  • eng

Conference Location

  • United States