Clinical use of serum CA-125 levels in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder.

Journal Article (Journal Article)

PURPOSE: It has recently been reported that serum CA-125 levels may serve as a prognostic indicator of extravesical disease in patients with bladder cancer. This study evaluated the role of CA-125 as a prognostic marker in patients with transitional cell carcinoma of the bladder undergoing radical cystectomy and urinary diversion. METHODS: Ninety-two consecutive patients underwent planned radical cystectomy and urinary diversion with curative intent (2005-2006). Serum CA-125 levels were obtained in all patients and correlations were made to clinical and operative findings and pathological outcomes. Outcomes were evaluated with regard to normal vs. abnormal CA-125 values and with regard to absolute values of CA-125 levels. Results were also stratified by short-term recurrence rates. RESULTS: Mean CA-125 values varied significantly by pathological stage and by resectability. No patient (0/56) with organ-confined disease (

Full Text

Duke Authors

Cited Authors

  • Kouba, EJ; Lentz, A; Wallen, EM; Pruthi, RS

Published Date

  • September 2009

Published In

Volume / Issue

  • 27 / 5

Start / End Page

  • 486 - 490

PubMed ID

  • 18555706

Electronic International Standard Serial Number (EISSN)

  • 1873-2496

Digital Object Identifier (DOI)

  • 10.1016/j.urolonc.2008.03.019


  • eng

Conference Location

  • United States