Engineering strategies to enhance nanoparticle-mediated oral delivery.


Journal Article (Review)

Oral delivery is the most preferred route of drug administration due to convenience, patient compliance and cost-effectiveness. Despite these advantages it remains difficult to achieve satisfactory bioavailability levels via oral administration due to the harsh environment of the gastrointestinal (GI) tract, particularly for biomacromolecules. One promising method to increase the bioavailability of macromolecular drugs such as proteins and nucleic acids is to encapsulate them in nanoparticles before oral administration. This review describes innovative strategies for increasing the efficacy of nanoparticle-mediated delivery to the GI tract. Approaches to optimize nanoparticle formulation by exploiting mucoadhesion, environmental responsiveness and external delivery control mechanisms are discussed. The application of recent advances in nanoparticle synthesis using supercritical fluids, microfluidics and imprint lithography to oral delivery are also presented, as well as possible strategies for incorporating nanoparticles into micro- and macroscale oral delivery devices.

Full Text

Cited Authors

  • Yamanaka, YJ; Leong, KW

Published Date

  • January 2008

Published In

Volume / Issue

  • 19 / 12

Start / End Page

  • 1549 - 1570

PubMed ID

  • 19017470

Pubmed Central ID

  • 19017470

Electronic International Standard Serial Number (EISSN)

  • 1568-5624

International Standard Serial Number (ISSN)

  • 0920-5063

Digital Object Identifier (DOI)

  • 10.1163/156856208786440479


  • eng