A finite element model for predicting the distribution of drugs delivered intracranially to the brain.

Published

Journal Article

Drug therapy to the central nervous system is complicated by the presence of the blood-brain barrier. The development of new drug delivery techniques to overcome this obstacle will be aided by a clear understanding of the transport processes in the brain. A rigorous theoretical framework of the transport of drugs delivered locally to the parenchyma has been developed using the finite element method. Magnetic resonance imaging has been used to track the transport of paramagnetic contrast markers in the brain. The information obtained by postprocessing spin-echo, T1-weighted, and proton density images has been used to refine the mathematical model that includes realistic brain geometry and salient anatomic features and allows for two-dimensional transport of chemical species, including both diffusive and convective contributions. In addition, the effects of regional differences in tissue properties, ventricular boundary, and edema on the transport have been considered. The model has been used to predict transport of interleukin-2 in the brain and study the major determinants of transport, at both early and late times after drug delivery.

Full Text

Cited Authors

  • Kalyanasundaram, S; Calhoun, VD; Leong, KW

Published Date

  • November 1997

Published In

Volume / Issue

  • 273 / 5

Start / End Page

  • R1810 - R1821

PubMed ID

  • 9374827

Pubmed Central ID

  • 9374827

Electronic International Standard Serial Number (EISSN)

  • 2163-5773

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpregu.1997.273.5.r1810

Language

  • eng